Inflammatory bowel diseases like Crohn’s disease and ulcerative colitis (UC) affect nearly 3.1 million adults in the U.S. and can significantly impact daily life. When standard medications fail to provide relief, patients often turn to advanced therapies like Entyvio infusion therapy, a treatment designed to directly reduce gut inflammation.
At Smart Infusion Therapy Services, we specialize in infusion therapy for patients in Eau Claire, Weston, and across Wisconsin. Our team works with your GI specialist to provide safe, efficient, and personalized care. If you're exploring new options for long-term IBD control, we can help.
Let’s take a closer look at how Entyvio works and why it might be the right choice for your treatment plan.
What Is Entyvio Used For?
Entyvio (vedolizumab) is an FDA-approved biologic used to treat:
- Moderately to severely active ulcerative colitis
- Moderately to severely active Crohn’s disease
Both conditions involve chronic inflammation in the gastrointestinal (GI) tract, and Entyvio is often prescribed when conventional treatments, like corticosteroids, immunosuppressants, or TNF inhibitors, are no longer effective or tolerated.
Unlike many biologics that affect the entire immune system, Entyvio specifically targets the GI tract, which helps reduce side effects and supports safer long-term use.
How Entyvio Reduces Inflammation in the GI Tract
Understanding the Entyvio mechanism of action helps explain why it's so effective. Entyvio blocks a specific protein called integrin α4β7, which guides white blood cells to the gut. In people with IBD, these immune cells mistakenly attack the GI lining, causing inflammation.
Entyvio stops this process by:
- Preventing immune cells from entering the gut
- Targeting only the intestinal tract (gut-selective)
- Reducing inflammation at the source
This targeted mechanism makes Entyvio a gut-specific immunomodulator, helping patients manage symptoms without suppressing the entire immune system.
Benefits of Entyvio for Crohn’s and Ulcerative Colitis
Patients who use Entyvio infusion therapy often experience:
- Reduced abdominal pain and diarrhea
- Improved bowel regularity
- Fewer flare-ups
- Reduced need for corticosteroids
- Enhanced quality of life
Because Entyvio works directly in the GI tract, many patients report improved symptom control with fewer systemic side effects compared to broader biologic therapies.
Entyvio Pen vs. Infusion: What’s the Difference?
Entyvio (vedolizumab) is available in two forms: intravenous (IV) infusion and subcutaneous injection (pen), offering flexibility based on your treatment plan and lifestyle needs.
Intravenous (IV) Infusion
The IV infusion is the traditional method and is typically administered by a licensed healthcare professional in a clinical setting, such as Smart Infusion Therapy Services. During this process, Entyvio is delivered directly into the bloodstream through a vein, ensuring accurate dosing and immediate absorption. This method is used during the initial phase of therapy induction.
Subcutaneous Injection (Entyvio Pen)
After completing the induction phase, some patients may be eligible to transition to the Entyvio pen, a prefilled auto-injector designed for self-administration at home. The pen delivers the medication just beneath the skin, typically in the abdomen or thigh, and provides a convenient alternative for those who prefer fewer clinic visits.
Treatment Timeline: Induction and Maintenance
Regardless of the method, Entyvio follows a structured dosing schedule:
- Induction Phase: Infusions at Week 0, Week 2, and Week 6
- Maintenance Phase: One dose every 8 weeks thereafter
The initial IV infusions are essential to build up therapeutic levels of the drug in your system. After this phase, your gastroenterologist will evaluate your response and decide whether to continue with IV infusions or switch you to the subcutaneous Entyvio pen.
Why Entyvio Is a Preferred Option for Long-Term GI Health
Entyvio is designed specifically to treat the gut, making it a strong option for managing Crohn’s disease and ulcerative colitis over time. It works by calming inflammation in the digestive tract without weakening your entire immune system. This helps reduce the chance of infections while still targeting the source of your symptoms.
Many patients use Entyvio for long-term care because it can help maintain remission, reduce or eliminate steroid use, and improve daily comfort. At Smart Infusion, we make treatment easier by offering private, stress-free infusion appointments and close coordination with your GI specialist.
What Are the Entyvio Side Effects?
While Entyvio is generally well-tolerated, it’s essential to be aware that, like any medication, it may cause side effects in some individuals. Most reactions are mild and temporary. Common side effects reported include headache, fatigue, nausea, joint discomfort, and cold-like symptoms such as congestion or cough.
In rare cases, more serious effects may occur, such as infusion-related reactions (like shortness of breath or rash), infections, or neurological complications such as progressive multifocal leukoencephalopathy (PML).
At Smart Infusion, your safety is our top priority. Our experienced infusion team closely monitors your response during each treatment session to catch and address any concerns early.
Success Rates and Patient Outcomes
Clinical trials and real-world studies show that Entyvio is highly effective:
- Many patients see symptom improvement after just 3 infusions.
- Long-term remission is possible with continued treatment.
- Patients report fewer hospitalizations and better day-to-day functioning
While responses vary, Entyvio remains one of the most well-tolerated and targeted therapies for IBD management.
How Entyvio Fits Into Your Overall GI Treatment Plan
Entyvio is typically introduced when:
- First-line treatments (like mesalamine or steroids) are ineffective
- You’ve tried and not responded well to TNF inhibitors (e.g., Humira)
- You need long-term maintenance with fewer side effects
A gastroenterologist will guide your treatment plan and may refer you to a specialty infusion provider, such as Smart Infusion, to initiate therapy.
Our team works closely with your GI specialist to coordinate preauthorization, scheduling, and insurance assistance, allowing you to focus on your healing.
Take the Next Step with Smart Infusion
Entyvio infusion therapy offers a powerful and personalized approach to managing Crohn’s disease and ulcerative colitis. With gut-targeted relief, fewer systemic effects, and a strong safety profile, it may be the key to regaining control of your health. At Smart Infusion Therapy Services, we simplify the process, from insurance coordination to providing care in a calm and supportive environment. Let us help you move forward with confidence.
Call us today at (608) 690-7210 to speak with our team, or book your appointment online to begin your personalized infusion therapy plan. Rediscover comfort and control, start your Entyvio journey today.
Frequently Asked Questions
WHAT IS ENTYVIO USED FOR?
Entyvio treats moderate to severe ulcerative colitis and Crohn’s disease when other medications don’t work.
HOW DOES ENTYVIO WORK?
It blocks immune cells from entering the gut and causing inflammation.
WHAT ARE THE COMMON ENTYVIO SIDE EFFECTS?
Headache, fatigue, joint pain, nausea, and mild respiratory infections.
IS THERE A DIFFERENCE BETWEEN ENTYVIO PEN VS INFUSION?
Yes. Infusion is used during induction; the pen may be used later for self-injection.
HOW LONG DOES ENTYVIO TAKE TO WORK?
Some patients improve within 6 weeks, while others may need more time.
