What to Expect During & After Entyvio Administration in Madison, WI

Starting Entyvio infusion therapy can feel overwhelming, especially if it’s your first time managing inflammatory bowel disease (IBD) with a biologic treatment. Understanding how the infusion process works, potential side effects, and what happens after treatment can help ease your mind.

At Smart Infusion Therapy Services, we specialize in providing patient-focused infusion care across Madison, Eau Claire, and Weston, WI. Our team works closely with your GI provider to ensure a safe, comfortable, and well-coordinated treatment experience.

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If you're starting or continuing Entyvio therapy for ulcerative colitis or Crohn's disease, here’s what you need to know.

What Is Entyvio Used For?

Entyvio (vedolizumab) is a prescription medication used to treat moderately to severely active ulcerative colitis and Crohn’s disease. It’s typically prescribed when other therapies haven’t provided sufficient relief or have caused unwanted side effects.

Unlike other biologics, Entyvio works by targeting the gut directly, rather than suppressing the entire immune system. This makes it a safer long-term option for many patients.

How Entyvio Works: Mechanism of Action

Entyvio works by blocking a specific protein called integrin α4β7, which guides white blood cells into the gastrointestinal tract. When these immune cells accumulate in the gut, they cause inflammation.

By preventing this from happening, Entyvio reduces inflammation in the GI tract, helping patients experience fewer symptoms, less frequent flare-ups, and improved overall gut health. This targeted mechanism of action means fewer systemic side effects compared to other immune-modulating drugs.

What Happens During an Entyvio Infusion Session

At Smart Infusion, your Entyvio therapy is administered through an intravenous (IV) infusion by trained medical staff. Here’s a step-by-step overview of what you can expect:

Before the Infusion:

• You’ll check in with our front desk and be guided to a private or semi-private infusion suite.
• A nurse will review your medical history and confirm your treatment plan.
• Your vitals will be taken to ensure you’re ready for infusion.

During the Infusion:

• Entyvio is delivered over a 30-minute IV infusion.
• Most patients relax, read, or use personal devices during the session.
• Our nursing staff monitors you throughout for any reactions.

After the Infusion:

• A short observation period (usually 30 minutes or less) ensures your safety before you go home.
• You may resume normal activities unless advised otherwise.

How Long the Infusion Process Takes and What to Bring

Plan to spend about 1 to 1.5 hours total at the infusion center, especially for your first few appointments.

We recommend bringing:

• A photo ID and insurance card
• A comfortable outfit with loose sleeves
• Snacks or drinks (if allowed)
• A book, tablet, or headphones for entertainment

Understanding the Entyvio Infusion Protocol

Entyvio treatment begins with an induction phase, followed by a maintenance phase:

• Induction Phase: Week 0, Week 2, and Week 6
• Maintenance Phase: Every 8 weeks after the third dose

This structured schedule helps establish and maintain remission, giving your body time to respond and adjust to the medication.

Your GI provider will determine whether to continue with IV infusions or, in some cases, transition to a subcutaneous injection (Entyvio pen) if appropriate.

Common Entyvio Side Effects and How to Manage Them

Most people tolerate Entyvio well, but it’s important to be aware of potential side effects:

Common side effects include:

• Headache
• Joint pain
• Nausea
• Fatigue
• Upper respiratory tract infections

Rare but serious risks:

• Allergic infusion reactions
• Liver issues
• Progressive multifocal leukoencephalopathy (PML)

Your Smart Infusion team monitors you closely during and after each session to manage any signs of complications early. If you experience any unusual symptoms after your appointment, call your provider immediately.

Post-Infusion Care and Follow-Up Appointments

After your infusion, you can typically go about your day as normal. Some patients may feel slightly tired, so it’s a good idea to plan for rest, especially after your first few treatments.

To make the most of your care:

• Track how you feel between doses
• Stay hydrated and eat well
• Report any side effects to your care team

You’ll also be scheduled for regular follow-up appointments with your gastroenterologist to assess progress and adjust your plan if needed.

Tips for Making the Most of Your Entyvio Treatment

Consistency and open communication with your care team are key. Here’s how to get the best results from Entyvio infusion:

• Stick to the infusion schedule: Delayed doses can affect your progress.
• Stay in touch with your GI provider: Let them know how you're feeling.
• Use patient support programs: Ask about copay assistance or financial support.
• Understand your insurance: The Entyvio infusion cost may vary depending on your provider and coverage. Our team at Smart Infusion helps verify insurance and explore financial support options.

Moving Forward with Confidence

Beginning Entyvio infusion therapy is a big step, but knowing what to expect can help make it easier. From your first visit to ongoing care, Smart Infusion Therapy Services is here to support your treatment journey with professionalism and compassion.

If you’re ready to take the next step in managing Crohn’s or ulcerative colitis, we’d love to help you feel better, faster. Call us at (608) 690-7210 or book your appointment online. Start feeling better with care that puts you first.

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Frequently Asked Questions