Multiple sclerosis (MS) is a lifelong neurological condition that impacts the brain and spinal cord, causing a wide range of symptoms that can vary from person to person. It affects millions of people globally and often involves periods of relapse and remission. While there is no known cure for MS at this time, ongoing research continues to bring new treatment options to the forefront. Among these, Briumvi is a recently approved MS biologic therapy that helps manage disease activity and reduce relapses for certain types of MS.
At Smart Infusion, we specialize in neurological infusion therapies that support stability and quality of life for people with MS. With infusion centers in Eau Claire, Weston, Madison, and Onalaska, WI, our goal is to make expert MS care more accessible and comfortable.
Let’s explore how Briumvi works, who it’s for, and what you need to consider before starting treatment.
What Is Briumvi and How Does It Work?
Briumvi (ublituximab-xiiy) is a biologic infusion medication approved by the FDA in 2022 to treat adults with relapsing forms of multiple sclerosis (MS). It’s part of a class of drugs known as anti-CD20 monoclonal antibodies, which work by targeting and depleting specific B cells in the immune system that drive MS inflammation and damage.
These B cells play a significant role in attacking the protective coating (myelin) of nerves in the brain and spinal cord. By reducing B cells, Briumvi lowers the likelihood of relapses and slows the progression of neurological damage, as shown on MRI scans.
Briumvi is infused through a vein (IV) and follows a convenient schedule: two initial infusions spaced two weeks apart, followed by maintenance infusions every six months. This allows for fewer treatment visits throughout the year, making it easier to stay on track.
It's currently approved to treat:
- Clinically Isolated Syndrome (CIS)
- Relapsing-Remitting MS (RRMS)
- Active Secondary Progressive MS (SPMS)
Briumvi vs Ocrevus: What's the Difference?
Both Briumvi and Ocrevus are CD20-directed monoclonal antibodies that target B cells in the immune system. However, there are important differences between the two that can influence your treatment experience:
- Infusion Time: Briumvi infusions take approximately one hour after the initial dose, while Ocrevus infusions typically take 2.5 to 3.5 hours. This may reduce time spent at the clinic.
- Dosing Schedule: Both drugs are administered twice yearly after initial loading doses, but Briumvi's shorter infusion times and faster onset of action make it more convenient for many.
- Antibody Structure: Briumvi is a glycoengineered antibody designed to enhance B-cell depletion, which may offer improved efficiency in some patients.
- Tolerability: Both treatments may cause infusion reactions (like fever, headache, or rash) and carry infection risks, though Briumvi may have a lower rate of severe reactions in clinical trials.
If you're weighing options between Briumvi vs Ocrevus, your neurologist will consider your health history, lifestyle, and disease activity before recommending one.
Is Briumvi Part of a Long-Term MS Treatment Plan?
Yes. Briumvi is designed to be part of a sustainable, long-term treatment approach—not a one-time solution. It helps reduce the number of relapses, slows the progression of physical disability, and minimizes visible disease activity on brain imaging.
Clinical trials (ULTIMATE I and II) demonstrated that Briumvi significantly reduced annual relapse rates and showed favorable MRI outcomes compared to standard treatments.
Patients who stick to their infusion schedule may experience:
- Fewer relapses each year
- Slowed worsening of symptoms
- More stable MRI scans
This allows many people with relapsing MS to maintain their independence and continue with work, school, or family responsibilities with fewer disruptions.
Who Is Eligible to Receive Briumvi?
Briumvi is FDA-approved for adults with relapsing forms of MS. Your care team will assess several factors before prescribing this medication:
You may be a good candidate if:
- You have been diagnosed with relapsing-remitting MS or active SPMS
- You are newly diagnosed and prefer a targeted, biologic approach
- You’re seeking a lower-burden, twice-yearly infusion option
Briumvi may not be right for you if:
- You have an active hepatitis B infection
- You’ve had prior severe reactions to monoclonal antibody drugs
- You’re currently pregnant, breastfeeding, or planning to conceive soon
Your doctor will order lab tests, including hepatitis B screening and blood counts, to evaluate safety before starting treatment.
What to Discuss With Your Doctor Before Starting
Before you begin treatment with Briumvi, be sure to talk to your provider about these topics:
- Is Briumvi more appropriate for me than other MS drugs?
- What are the main benefits and side effects I should expect?
- Will Briumvi interfere with my other medications?
- Should I get any vaccines beforehand? (Live vaccines should be avoided during and shortly before treatment.)
- What’s the plan if I want to become pregnant later?
Ask how your infusion center supports patients. At Smart Infusion, we help with everything from coordinating care to explaining insurance benefits.
What Are the Side Effects of Briumvi?
Like all medications, Briumvi can cause side effects. The most common are infusion-related reactions that typically occur during or within 24 hours after treatment:
- Fever or chills
- Headache
- Fatigue
- Nausea
- Skin rash or itching
- Shortness of breath (rare)
To minimize these effects, patients are often given pre-medication like antihistamines and steroids.
Less common but serious risks include:
- Hepatitis B reactivation: Requires screening before starting.
- PML (progressive multifocal leukoencephalopathy): A rare brain infection; providers monitor for early signs.
- Low immune globulin levels: May require additional monitoring over time.
Our Smart Infusion team monitors patients before, during, and after infusions for safety and comfort.
How to Prepare for Your First Briumvi Infusion
Preparing for your first Briumvi infusion can help ease anxiety and ensure a smoother experience:
- Follow your provider’s instructions about pre-medication
- Eat beforehand: A light meal can help with nausea
- Stay hydrated before and after treatment
- Wear comfy clothes with easy access to your arms
- Bring entertainment (headphones, a book, or a tablet)
At Smart Infusion, our clinics are designed for comfort. Private infusion chairs, Wi-Fi access, and supportive nursing staff make your visit as relaxing as possible.
What to Expect After Treatment
After your infusion, you might feel tired or have mild flu-like symptoms for a day. Here’s how to support your recovery:
- Rest when needed and avoid overexertion
- Drink fluids to help your body process medications
- Eat nourishing foods to support your immune system
- Keep track of side effects and contact your provider if anything unusual occurs
Our nurses will send you home with clear aftercare instructions and follow up as needed.
Why Choose Smart Infusion for Your Briumvi Therapy
Smart Infusion Therapy Services LLC is a place where personalized care and clinical expertise meet. We’re dedicated to helping individuals living with MS receive safe, effective, and compassionate infusion care. Here’s what you can expect when you choose us for Briumvi therapy:
- Specialized MS infusion nurses trained in neurology and biologic therapies
- One-on-one attention thanks to our low nurse-to-patient ratios
- Comfortable private infusion suites equipped with Wi-Fi, entertainment, and quiet space to relax
- Flexible scheduling options to fit your routine, including evenings and weekends
- Clear, upfront billing practices to help avoid surprise
- Convenient clinic locations in Eau Claire, Weston, Middleton, and Onalaska, Wisconsin
Our goal is to make your infusion experience easier, calmer, and more reassuring, from your first visit to your long-term care plan.
Let’s Take the Next Step Together
Briumvi is one of the most promising new medicines for MS, offering targeted, twice-yearly therapy that fits into your life. If you’re exploring new MS biologic therapies or wondering how to manage MS symptoms more effectively, Smart Infusion is here to guide you every step of the way.
Ready to take the next step in your MS treatment journey? Call us today at (608) 690-7210or request your appointment online at mysmartinfusion.com/appointment_request. With convenient locations, compassionate care is always within reach.
Book An Appointment
Frequently Asked Questions
Is Briumvi a cure for MS?
No. Briumvi doesn’t cure MS but helps control disease activity and reduce relapses.
How often will I need an infusion?
After your first two doses, Briumvi is given every 6 months.
Can I switch from another MS medication?
Yes, but timing and overlap must be carefully managed with your doctor.
Can I receive vaccines on Briumvi?
Avoid live vaccines while on treatment. Ask your provider which vaccines you may need before starting.
Does insurance cover Briumvi?
Coverage varies, but many plans include Briumvi. Our staff can assist with prior authorizations.
